P-133 PROSPECTIVE INTERVENTIONAL STUDY OF THE ANALGESIC EFFICACY OF A CYCLOMESH™ PARIETAL REINFORCEMENT IMPLANT SOAKED IN ROPIVACAINE HYDROCHLORIDE 10MG/ML IN THE TREATMENT FOR UNCOMPLICATED INGUINAL HERNIA

Abstract Background 20–30% of patients operated for inguinal hernia will present early postoperative pain (EPP) which is, after the organizational causes, first cause conversion from ambulatory to traditional hospitalization. The objective this study was evaluate interest a parietal prosthesis (Cyclomesh ™) soaked with ropivacaine in management EPP. Materials and Methods This is randomized, phase III, comparative superiority, double-blind, international multicentre study. From October 2019 February 2022, 290 underwent surgery placement or saline prosthesis. primary endpoint H6 coughing assessment (EVA). Results intention treat population (ITTp) composed 150 group 140 placebo group, per-protocol (PPp) it 125 115. type had no significant effect on pain, either ITTp (3.3 vs 3.2, p=0.12) PPp 3.7, p=0.15). ropivaciane resulted decrease overall at H2 (2.3 p<0.0001), H4 3.1, p<0.0001) 2.7, p=0.0039). Regarding painkillers consumption, complications number conversions, there difference between two groups. Conclusion did not reduce but allowed over 6 hours could simplify patients.